After being taken up by macrophages, the bacteria proliferate in the affected lymph nodes, causing inflammation and swelling to occur, i.e., buboes. It is caused by the bacterium, Yersinia pestis. Plague bacteria are killed within a few hours of exposure to sunlight, although they may persist for several weeks in water and on moist grains and pulses. The infection exists in three major plague forms: bubonic, septic, and pneumonic. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague has caused some of the most-devastating epidemics in history. The disease follows urban and sylvatic cycles and is manifested in bubonic and pneumonic forms [note: bubo is derived from a Greek word for groin]. Pneumonic plague, or lung-based plague, is the most virulent form of plague. Plague is a highly contagious, life-threatening infection now present in the US mainly in rural or semirural areas of the Southwest. Primary plague pneumonia has a shorter incubation period of 1–4 days. Plague Disease. Pneumonic plague: human-to-human via air-borne droplets associated with coughing. Plague is a disease that affects humans and other mammals. It was the disease behind the Black Death of the 14th century, … Plague is transmitted from animal to animal and from animal to human by the bites of infective fleas. Author: The Overmind Difficulty: Mega Brutal Gameplay. Plague or black death is an infection of rodents caused by Yersinia pestis and accidentially transmitted to humans by the bite of infected fleas. Plague is infamous for killing millions of people in Europe during the Middle Ages. Dog-to-human transmission was reported in a 2014 outbreak in Colorado. Less frequently, the organism enters through a break in the skin by direct contact with tissue or body fluids of a plague–infected animal, for instance, in the process of skinning a rabbit or other animal. Most often transmitted by the bite of infected rodent fleas. Plague may cause massive, often suppurative lymphadenopathy (buboes), severe pulmonary infection, and/or septicemia. [] Survival of the bacillus in nature depends on flea-rodent interaction, and human infection does not contribute to the bacteria's persistence in nature. Any person with pneumonic plague may transmit the disease via droplets to other humans. The bubonic plague is the most common form of infection and targets the victim’s lymphatic system. Pneumonic plague occurs when Y. pestis infects the lungs, and is the most deadly form of the disease. Incubation can be as short as 24 hours. Bubonic plague: via the bite of infected fleas. Strategy 1 Basic Information. Modes of Transmission. From 1–7 days; may be a few days longer in immunised people who develop illness. Diagnosis of infection NOTE: Unlike cats, dogs do not appear to develop pneumonic plague. I came up with a Cure Mode strategy which works for Bacteria on Mega Brutal.With some modifications, it seems to work on Viruses, Parasites, and a few other disease types but not quite as well since those are harder to defeat than Bacteria, and I have mostly just tested it on Bacteria. NOTE: Cats also can develop pneumonic plague, and cat to human transmission has been reported. Bubonic plague can advance and spread to the lungs, which is the more severe type of plague called pneumonic plague. Spread of infection Incubation period. Plague, infectious disease caused by Yersinia pestis, a bacterium transmitted from rodents to humans by the bite of infected fleas. Plague is most commonly transmitted from rodent to human by the bite of an infected flea, especially the oriental rat flea Xenopsylla cheopis. 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